Crystalline...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 311/58 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2253284

The present invention provides novel crystalline (-)-3R,4R-trans-7-methoxy-2,2- dimethyl-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane, hydrogen fumarate useful for reducing or preventing bone loss as well as pharmaceutical compositions containing the same. A process for preparing (-)-3R,4R-trans-7- methoxy-2,2-dimethyl-3-phenyl-4-{4-[2-(pyrrolindin-1- yl)ethoxy]phenyl}chromane, hydrogen fumarate is described.

La présente invention se rapporte à un nouveau cristallin (-)-3R,4R-trans-7-méthoxy-2,2-diméthyl-3-phényl-4-{4-[2-pyrrolidin-1-yl)éthoxy]phényl}chromane, fumarate d'hydrogène utile pour réduire ou prévenir la perte osseuse. L'invention se rapporte également à des compositions pharmaceutiques contenant ces composés. Un procédé de préparation des composés précités est également décrit.

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