Crystalline (-)-6- chloro-4- cyclopropylethynyl-...

Details Crystalline (-)-6- chloro-4- cyclopropylethynyl-... Crystalline (-)-6- chloro-4- cyclopropylethynyl-...

C - Chemistry, Metallurgy

07

D

C07D 239/80 (2006.01) A61K 31/505 (2006.01) A61P 31/18 (2006.01) C07D 239/78 (2006.01)

Patent

CA 2345516

The potent reverse transcriptase inhibitor (-)-6-Chloro-4-cyclopropylethynyl-4- trifluoromethyl-3,4-dihydro-2(1H)-quinazolinone is produced in solvate and crystalline form. These forms are designated Forms 1 and 2, and are characterized by x-ray powder diffraction and differential scanning calorimetry. Pharmaceutical compositions and methods are useful for the treatment of the human immunodeficiency virus (HIV).

Selon cette invention, on produit un puissant inhibiteur de la reverse-transcriptase, (-)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-3,4-dihydro-2(1H)-quinazolinone, sous une forme soluble ou cristalline. Ces formes, désignées "forme 1" et "forme 2", sont caractérisées par la diffraction des rayons X dans la poudre et par une calorimétrie à balayage différentielle. Les compositions pharmaceutiques et les procédés de l'invention peuvent servir dans le traitement du virus de l'immunodéficience humaine, ou VIH.

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