Crystalline amrubicin hydrochloride

Details Crystalline amrubicin hydrochloride Crystalline amrubicin hydrochloride

C - Chemistry, Metallurgy

07

H

C07H 15/252 (2006.01) A61K 31/704 (2006.01) A61P 35/00 (2006.01) C30B 7/00 (2006.01) C30B 11/00 (2006.01)

Patent

CA 2311486

P-Type crystalline amrubicin hydrochloride having the formula Image and having a powder x-ray diffraction pattern having average values of diffraction angle (2.theta.) and relative intensity as given in the following table: Image has excellent thermal stability and is used in production of freeze-dried formulations.

L'invention concerne un chlorhydrate d'amrubicine cristallin de type beta , présentant un diagramme de diffraction des rayons X sur poudre dont les valeurs moyennes des angles de diffraction (2 theta ) et des intensités relatives figurent dans le tableau (1). Ce chlorhydrate présente également une excellente stabilité thermique et sert dans la production de formulations lyophilisées.

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