C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/496 (2006.01)
Patent
CA 2609353
The present invention relates to non-hydrate crystalline forms of 4-amino- 5- fluoro-3 -[6-(4-methylpiperazin- 1 -yl)- 1 H-benzimidazol-2-yl] - 1 H-quinolin- 2-one lactic acid salts, solid pharmaceutical formulations containing the same and methods of use. The present invention also relates to crystalline hydrates of 4-arnino-5-fiuoro-3-[6-(4- methylpiperazin-l-yl)-lH-benzimidazol-2-yl]-lH- quinolin-2-one lactic acid salts, pharmaceutical formulations containing the same and methods of use related thereto. The present invention further relates to crystalline solvates of 4-amino-5-fluoro-3-[6-(4- methylpiperazin-l-yl)-lH- benzimidazol-2-yl]-lH-quinolin-2-one lactic acid salts.
La présente invention concerne des formes cristallines non hydratées de sels d'acide lactique 4-amino- 5-fluoro-3 -[6-(4-méthylpipérazin- 1 -yl)- 1 H-benzimidazol-2-yl] - 1 H-quinolin-2-one, des formulations pharmaceutiques les contenant et des procédés de leur utilisation. La présente invention concerne aussi des hydrates cristallins de sels d'acide lactique 4-amino-5-fiuoro-3-[6-(4- méthylpipérazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one, des formulations pharmaceutiques les contenant et des procédés de leur utilisation. La présente invention concerne aussi des solvates cristallins de sels d'acide lactique 4-amino-5-fluoro-3-[6-(4- méthylpipérazin-l-yl)-lH-benzimidazol-2-yl]-lH-quinolin-2-one.
Chou Joyce
Gullapalli Rampurna
Harwood Eric
Okhamafe Augustus
Ryckman David
Fetherstonhaugh & Co.
Novartis Ag
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