Crystalline and pure modafinil, and process of preparing the...

Details Crystalline and pure modafinil, and process of preparing the... Crystalline and pure modafinil, and process of preparing the...

C - Chemistry, Metallurgy

07

C

C07C 317/44 (2006.01) A61K 31/165 (2006.01) C07C 315/06 (2006.01)

Patent

CA 2685310

The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further provides new crystalline Forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil Forms II-IV and VI.

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