Crystalline antifungal polymorph

Details Crystalline antifungal polymorph Crystalline antifungal polymorph

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/41 (2006.01) A61K 31/495 (2006.01) C07D 241/00 (2006.01) C07D 249/00 (2006.01) C07D 307/00 (2006.01)

Patent

CA 2305803

The crystalline polymorph Form I of (-)-4-[4-[4-[4-[[(2R-cis)-5-(2,4- difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-yl- methyl)furan-3-yl]methoxy]phenyl]-1-piperazinyl]phenyl-2,4-dihydro-2-[(S)-1- ethyl-2(S)-hydroxylpropyl]-3H-1,2,4-triazol-3-one represented by formula (I), pharmaceutical compositions containing such a polymorph and methods of using such a polymorph to treat fungal infections in mammals are disclosed.

L'invention porte sur la forme cristalline polymorphe du (-)-4-[4- [4-[4-[ [(2R-cis)-5-(2, 4-difluorophenyl) tetrahydro-5-(1H-1, 2,4-triazol- 1-ylmethyl)furan-3-yl] phenyl] -1-piperazinyl] phenyl-2,4-dihydro-2- [(S)-1-ethyl-2(S)- hydroxylpropyl]-3H-1, 2,4-triazol-3-one de formule (I), des préparations pharmaceutiques le contenant, et sur ses procédés d'utilisation pour le traitement de mycoses chez les mammifères.

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