Crystalline base of citalopram

Details Crystalline base of citalopram Crystalline base of citalopram

C - Chemistry, Metallurgy

07

D

C07D 307/87 (2006.01) A61K 31/343 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2360287

The present invention relates to the crystalline base of the well known antidepressant drug citalopram,1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofurancarbonitrile, formulations of said base, a process for the preparation of purified salts of citalopram, such as the hydrobromide, using the base, the salts obtained by said process and formulations containing such salts.

Cette invention concerne la base cristalline du citalopram, un médicament antidépresseur bien connu, le 1-[3-(diméthylamino)propyl]-1-(4-fluorophényl)-1,3-dihydro-5-isobenzofurancarbonitrile, des formulations de cette base, un procédé permettant la préparation de sels purifiés de citalopram, tels que le bromhydrate, au moyen de cette base, ainsi que les sels obtenus par ce procédé et des formulations contenant ces sels.

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