Crystalline benzothiazine dioxide salts

C - Chemistry – Metallurgy – 07 – D

Patent

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260/243.21

C07D 417/12 (2006.01)

Patent

CA 1209571

CRYSTALLINE BENZOTHIAZINE DIOXIDE SALTS Abstract The water-soluble ethylenediamine, monoethanol- amine and diethanolamine salts of N-(2-pyridyl)-2- methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide have been prepared. These novel crystalline salts are useful in therapy as non- steroidal anti-arthritic agents. Methods for preparing these salts from the corresponding acidic starting material and the appropriate amine base are provided.

403957

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