Crystalline bis[(e)-7- [ 4-(4- fluorophenyl)- 6-isopropyl-2-...

Details Crystalline bis[(e)-7- [ 4-(4- fluorophenyl)- 6-isopropyl-2-... Crystalline bis[(e)-7- [ 4-(4- fluorophenyl)- 6-isopropyl-2-...

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2356212

The present invention relates to a crystalline form of the compound bis[(E)-7- [ 4-(4- fluorophenyl)- 6-isopropyl-2- [methyl (methylsulfonyl) amino] pyrimidin-5-yl] (3R, 5S)-3, 5-dihydroxyhept -6-enoic acid]calcium salt, as well as processes for its manufacture and pharmaceutical compositions comprising the crystalline form, which is useful as an agent for treating hyperlipidemia, hypercholesterolemia and atherosclerosis.

L'invention concerne une forme cristalline du composé sel de calcium[(E)-7-[ 4-(4- fluorophényl)- 6-isopropyl-2- [méthyl (méthylsulfonyl) amino] pyrimidine-5-yl] (3R,5S)-3, 5-dihydroxyhept -6-acide énoïque], ainsi que ses procédés de fabrication et des composition pharmaceutiques comprenant ladite forme cristalline, utile en tant qu'agent pour le traitement de l'hyperlipidemie, l'hypercholestérolémie et l'athérosclérose.

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