C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01)
Patent
CA 2539067
The invention relates to a crystalline compound of 4'-demethyl-4'-phosphate-2",3"-bispentafluorophenoxyacetyl-4",6"-ethylidene-.beta.-D-epipodophyllotoxin glucoside in its free form or solvated with ethanol, advantageously provided in the form of a hemiethanolate solvate. The invention also relates to a method for preparing these compounds and to their use as an anticancer drug.
La présente invention concerne un composé cristallin 4'-déméthyl-4'- phosphate~2",3"-bispentafluorophénoxyacétyl-4",6"-éthylidène-.beta.-D- glucoside d'épipodophyllotoxine sous forme libre ou sous forme de solvate avec l'éthanol, avantageusement sous forme de solvate hémiéthanolate. Elle concerne également leur procédé de préparation et leur utilisation en tant que médicament anticancéreux.
Guminski Yves
Imbert Thierry
Kruczynski Anna
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Pierre Fabre Medicament
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