Crystalline cyclodextrin inclusion complexes of ranitidine...

Details Crystalline cyclodextrin inclusion complexes of ranitidine... Crystalline cyclodextrin inclusion complexes of ranitidine...

C - Chemistry, Metallurgy

08

B

C08B 37/16 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61K 31/715 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2157190

The present invention relates to cyclodextrin inclusion complexes of ranitidine hydrochloride which exhibit a novel, to date unknown crystalline structure, being significantly different from those of known "Form 1 and 2" and to the preparation of such inclusion complexes. The inclusion complexes are prepared from aqueous common solution or suspensions of ranitidine hydrochloride and cyclodextrin by removal of water. As complexing agents .alpha., .beta.- and gamma-cyclodextrins, their alkylated, hydroxy alkylated derivates or their suitable mixtures are utilized. Finally, the invention concerns pharmaceutical compositions comprising the new complexes.

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