C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/037 (2006.01) A61K 38/05 (2006.01) A61P 17/06 (2006.01) C07K 1/107 (2006.01) C07K 1/16 (2006.01) C07K 1/30 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C30B 7/14 (2006.01)
Patent
CA 2672369
A process for making pure crystalline D-isoglutamyl-D-tryptophan is provided which includes the step of deprotecting essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan or its diester to yield essentially pure D-isoglutamyl-D- tryptophan. A process is also provided for the preparation of pure mono ammonium salt of D-isoglutamyl-D-tryptophan from essentially pure N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan. D-isoglutamyl-D-tryptophan, ammonium salt (1 :1) is a stable pharmaceutical solid.
L'invention concerne un procédé de fabrication de D-isoglutamyl-D-tryptophan cristallin pur qui consiste à déprotéger principalement du N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan pur ou son diester pour produire du D-isoglutamyl-D- tryptophan principalement pur. L'invention concerne également un procédé permettant de préparer du sel de monoammonium pur de D-isoglutamyl-D-tryptophan à partir de N-tert-butoxycarbonyl-D- isoglutamyl-D-tryptophan principalement pur. Le D-isoglutamyl-D-tryptophan, sel d'ammonium (1 :1) est un solide pharmaceutique stable.
Leung-Toung Regis
N'zemba Blaise
Tam Tim Fat
Wang Yingsheng
Yu Lily
Apotex Technologies Inc.
Mckinnon Graham J.k.
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