Crystalline derivative of 2- (5-chlorothien-2-yl)-n-...

Details Crystalline derivative of 2- (5-chlorothien-2-yl)-n-... Crystalline derivative of 2- (5-chlorothien-2-yl)-n-...

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2508699

(E)-2-(5-Chlorothien-2-yl)-N-{(3S)-1-[(1S)-1-methyl-2-morpholin-4-yl-2- oxoethyl]-2-oxopyrrolidin-3-yl}ethenesulfonamide in substantially crystalline form, pharmaceutical formulations thereof, processes for preparing it, and its use inmedicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.

L'invention concerne des (E)-2-(5-chlorothiène-2-yle)-N-{(3S)-1[(1S)-1-méthyle-2-morpholine-4-yle-2-oxoéthyle]-2-oxopyrrolidine-3-yle}éthène-sulfonamides sous forme sensiblement cristalline, des formulations pharmaceutiques desdits composés, des procédés de préparation correspondants et leur utilisation dans le domaine médical, notamment pour améliorer un état clinique pour lequel un inhibiteur du facteur Xa est indiqué.

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