C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 501/46 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01)
Patent
CA 2101571
ABSTRACT The present invention relates to a new crystalline dihydrochloride dihydrate salt of the cephalosporin antibiotic, cefepime. In particular, this invention provides a temperature and moisture stable crystalline dihydrochloride dihydrate form of cefepime having enhanced stability and a specific x-ray powder diffraction pattern as described herein. The present invention also provides physical admixtures of the new crystalline dihydrochloride dihydrate salt of cefepime with a pharmaceutically acceptable non-toxic organic or inorganic base. In particular, this invention provides physical admixtures of a temperature and moisture stable crystalline dihydrochloride dihydrate form of cefepime having a specific X-ray powder diffraction pattern as described herein with L(+) arginine.
Garofalo Elizabeth A.
Kaplan Murray A.
Lim Gary M. F.
Nassar Munir N.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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