C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/18 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2333550
The potent reverse transcriptase inhibitor Efavirenz is produced in crystalline form. Crystalline Efavirenz exists in several physical forms which are designated Forms 1, 2, 3, 4 and 5 and are characterized by x-ray powder diffraction and differential scanning calorimetry. Pharmaceutical compositions and methods are useful for the treatment of the human immunodeficiency virus (HIV).
La présente invention concerne Efavirenz, le puissant inhibiteur de transcriptase inverse, produit sous forme cristalline. L'Efavirenz cristalline existe sous diverses formes physiques, désignées formes 1, 2, 3, 4 et 5. Il est caractérisé par la diffraction des rayons X à travers la poudre et par une calorimétrie de balayage différentielle. Les compositions pharmaceutiques le contenant ainsi que les procédés correspondants sont utiles pour le traitement du virus de l'immunodéficience humaine (VIH).
Maurin Michael B.
Moore James R.
Rabel Shelley R.
Radesca Lilian A.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Dupont Pharmaceuticals Company
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