Crystalline fluoroquinolone arginine salt form

Details Crystalline fluoroquinolone arginine salt form Crystalline fluoroquinolone arginine salt form

C - Chemistry, Metallurgy

07

D

C07D 455/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/4745 (2006.01) A61P 31/04 (2006.01) C07D 455/06 (2006.01)

Patent

CA 2459407

The invention relates to the new arginine salt forms of RS-(.plusmn.)-9-fluoro- 6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H- benzo~i,j~quinolizine-2-carboxylic acid, S-(-)-9-fluoro-6,7-dihydro-8-(4- hydroxypiperidin-1-yl)-5-methyl-1-oxo-1H,5H-benzo~i,j~quinolizine-2-carboxylic acid, R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo- 1H,5H-benzo~i,j~quinolizine-2-carboxylic acid, a process for their preparation and pharmaceutical formulations which comprise those arginine salt forms as the active ingredient for its use in treating microbial infections.

L'invention concerne de nouvelles formes de sel d'arginine d'acide RS-(.plusmn.)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-méthyl-1-oxo-1H,5H-benzoÝi,j¨quinolizine-2-carboxylique, d'acide S-(-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-méthyl-1-oxo-1H,5H-benzoÝi,j¨quinolizine-2-carboxylique, d'acide R-(+)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidin-1-yl)-5-méthyl-1-oxo-1H,5H-benzoÝi,j¨quinolizine-2-carboxylique, un procédé de préparation de celles-ci ainsi que des formulations pharmaceutiques comprenant ces formes de sel d'arginine en tant qu'ingrédient actif et destinées à être utilisées dans le traitement d'infections microbiennes.

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