Crystalline form ii of cabergoline

Details Crystalline form ii of cabergoline Crystalline form ii of cabergoline

C - Chemistry, Metallurgy

07

D

C07D 457/06 (2006.01)

Patent

CA 2399540

Crystalline form II of cabergoline, a pharmaceutical composition containing it and a process for its preparation are disclosed. The process may comprise crystallization from a solution of raw cabergoline in an organic solvent at low temperatures or submitting to a slurry procedure a mixture of cabergoline Forms I and II in a solvent at a temperature below about 30 ~C.

L'invention porte sur la forme cristalline II de la cabergoline, sur une préparation pharmaceutique la contenant, et sur son procédé de préparation lequel peut consister à cristalliser une solution de cabergoline brute dans un solvant à basse température ou a soumettre à un processus d'élaboration d'une suspension épaisse, un mélange des formes I and II de la cabergoline, placé dans un solvant à une température inférieure à environ 30 DEG C.

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