Crystalline form of a biphenyl compound

Details Crystalline form of a biphenyl compound Crystalline form of a biphenyl compound

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4709 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2575874

The invention provides a crystalline 1,2-ethanedisulfonic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo- 1,2-dihydroquinolin-5-yl)ethylamino]methyl}-5- methoxyphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also provides pharmaceutical compositions comprising such a salt or prepared using such a salt; processes and intermediates for preparing such a salt; and methods of using such a salt to treat a pulmonary disorder.

L'invention concerne un sel cristallin d'acide 1,2-éthanedisulfonique d'ester d'acide biphényl-2-ylcarbamique 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dishydroquinolin-5-yl)éthylamino]méthyl}-5-méthoxyphénylcarbamoyl)éthyl]pipéridin-4-yl ou un solvate de celui-ci. L'invention concerne également des compositions pharmaceutiques contenant ledit sel ou préparées au moyen dudit sel; ainsi que des procédés et des intermédiaires de préparation de ce sel, et des méthodes d'utilisation de ce sel dans le traitement d'un trouble pulmonaire.

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