Crystalline form of a dihydropteridione derivative

Details Crystalline form of a dihydropteridione derivative Crystalline form of a dihydropteridione derivative

C - Chemistry, Metallurgy

07

D

C07D 475/00 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2695406

The present invention relates to a crystalline form a dihydropteridione derivative, namely a crystalline form of the free base N-- [trans-4- [4- (cyclopropylmethyl) --1-piperazinyl] cyclohexyl] -4- [[(7R) -7-ethyl-5,6,7,8 - tetrahydro - 5 -methyl - 8 - (1 -methylethyl) - 6 - oxo - 2 -- pteridinyl] amino] - 3 -methoxy -benz amide of structure (I), to a process for the manufacture thereof, and to the use thereof in a pharmaceutical composition.

La présente invention concerne une forme cristalline d'un dérivé de dihydroptéridione, à savoir une forme cristalline de la base libre N-[trans-4-[4-(cyclopropylméthyl)-1-pipérazinyl]cyclohexyl]-4-[[(7R)-7-éthyl-5,6,7,8-tétrahydro-5-méthyl-8-(1-méthyléthyl)-6-oxo-2-ptéridinyl]amino]-3-méthoxybenzamide de structure (I), un procédé pour la fabrication de celui-ci et l'utilisation de celui-ci dans une composition pharmaceutique.

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