Crystalline form of a phenylethanolamine, the preparation...

Details Crystalline form of a phenylethanolamine, the preparation... Crystalline form of a phenylethanolamine, the preparation...

C - Chemistry, Metallurgy

07

C

C07C 217/74 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) C07C 213/10 (2006.01) C07C 219/26 (2006.01)

Patent

CA 2450213

The invention relates to the B form of ethyl [(7S)7-[(2R)2-(3-chlorophenyl)-2-hydroxyethylamino]- 5,6,7,8-tetrahydronaphthalen-2-yloxy] acetate chlorohydrate, applicable as an antidepressant medicament, with the following particular physical characteristics: characteristic IR absorption peaks (cm-1): 2780, 2736, 1722, 1211; melting point: 129+/-2°C; characteristic X-ray powder diffraction pattern peaks (at approx. 0.1(2e): 7,69 - 9,83 - 13,95 - 16,58 - 18,70 - 20,40 - 21,57 - 23,40 - 24,15 - 25,64. The product may be obtained by salt-formation or recrystallisation of the salt from an alcohol.

L'invention a pour objet la forme B du chlorhydrate de [(7S) 7-[(2R) 2-(3-chlorophényl)-2-hydroxyéthylamino]-5,6,7,8-tetrahydronaphtalen-2-yloxy]-acétate d'éthyle utile comme médicament, qui présente notamment les caractéristiques physiques suivantes: pics d'absorption IR caractéristiques (cm?-1¿): 2780, 2736, 1722, 1211; point de fusion: 129+/-2 ·C; raies caractéristiques du diagramme de diffraction des rayons X sur poudre (à 0,1(2.theta. près): 7,69 - 9,83 - 13,95 - 16,58 - 18,70 - 20,40 - 21,57 - 23,40 - 24,15 - 25,64. Le produit peut être obtenu par salification de la base ou recristallisation du sel dans un alcool .

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