Crystalline form of a quinolinone-carboxamide compound

Details Crystalline form of a quinolinone-carboxamide compound Crystalline form of a quinolinone-carboxamide compound

C - Chemistry, Metallurgy

07

D

C07D 451/04 (2006.01) A61K 31/40 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2603654

The invention provides a crystalline hydrochloride salt of 1-isopropyl-2-oxo- 1,2-dihydroquinoline-3-carboxylic acid {(1S,3R,5R)-8-[(R)-2-hydroxy-3- (methanesulfonyl-methyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with 5 HT4 receptor activity, and processes useful for preparing such crystalline salt forms.

L'invention concerne un chlorhydrate cristallin d'acide 1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxylique {(1S,3R,5R)-8-[(R)-2-hydroxy-3-(méthanesulfonyl-méthyl-amino)propyl]-8-azabicyclo[3.2.1]oct-3-yl}amide ou un solvate de celui-ci. L'invention concerne également des compositions pharmaceutiques comprenant ces formes de sel cristallin, des méthodes d'utilisation de ces formes de sel cristallin pour traiter des maladies associées à l'activité de récepteur de 5 HT4 et des procédés utiles pour la préparation de ces formes de sel cristallin.

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