C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/70 (2006.01) A61K 31/415 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2736102
The invention provides a crystalline freebase form of 4'-{2-ethoxy-4-ethyl-5-[((S)-2-mercapto-4-methylpentanoy- lamino)methyl]imidazol-1-ylmethyl}-3'-fluorobiphenyl-2-carboxylic acid. This invention also provides pharmaceutical composi-tions comprising the crystalline compound, processes and intermediates for preparing the crystalline compound, and methods of using the crystalline compound to treat diseases such as hypertension.
L'invention concerne une forme cristalline à base libre de lacide 4'-{2-éthoxy-4-éthyl-5-[((S)-2-mercapto-4-méthylpentanoylamino)méthyl]imidazol-1-ylméthyl}-3'-fluorobiphényl-2-carboxylique; des préparations pharmaceutiques comprenant le composé cristallin; les procédés et intermédiaires de préparation du composé cristallin; et des méthodes dutilisation du composé cristallin pour traiter des maladies telles que lhypertension.
Chao Robert
Zhang Weijiang
Theravance Inc.
Torys Llp
LandOfFree
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