Crystalline form of bis...

Details Crystalline form of bis... Crystalline form of bis...

C - Chemistry, Metallurgy

07

D

C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01)

Patent

CA 2537962

Two polymorphic forms of bis [(E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6 -enoic acid] calcium salt, processes for making them and their use as HMG Co-A reductase inhibitors are described.

La présente invention se rapporte à deux formes polymorphes de sel de calcium de bis[acide (E)-7-[4-(4-fluorophényl)-6-isopropyl-2-[méthyl(méthylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-énoïque], à leur procédés de production et à leur utilisation en tant qu'inhibiteurs de la HMG Co-A réductase.

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