C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/4178 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2695729
The present disclosure generally relates to a crystalline form of methyl ((1S)- 1-(((2S>2-(5-(4'-(2-((2S)-1-((2S)-2-- ((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4- biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2- methylpropyl)carbamate dihydrochloride salt. The present disclosure also generally relates to a pharmaceutical composition comprising a crystalline form, as well of methods of using a crystalline form in the treatment of Hepatitis C and methods for obtaining such crystalline form.
La présente invention concerne d'une façon générale une forme cristalline de dihydrochlorure de méthyl ((1S)-1-(((2S>2-(5-(4'-(2-((2S)-1-((2S)-2-((méthoxycarbonyl)amino)-3-méthylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-5-yl)-4-biphénylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-méthylpropyl)carbamate. L'invention concerne également une composition pharmaceutique comprenant une forme cristalline, ainsi que des procédés d'utilisation d'une forme cristalline dans le traitement de l'hépatite C, et des procédés d'obtention d'une telle forme cristalline.
Gao Qi
Kim Soojin
Yang Fukang
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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