Crystalline forms glyt1

Details Crystalline forms glyt1 Crystalline forms glyt1

A - Human Necessities

61

K

A61K 31/444 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2673667

The present invention relates to four distinct crystalline forms and to an amorphous form of [4-(3-Fluoro-5-trifluoromethyl-pyridin-2-yl)-piperazin-l-yl]-[5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-methanone, and to their use in the preparation of pharmaceutical compositions. The compounds of present invention are suitable for the preparation of a medicament useful for treating psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.

La présente invention concerne quatre formes cristallines distinctes et une forme amorphe de [4-(3-fluoro-5-trifluorométhyl-pyridin-2-yl)-pipérazin-1-yl]-[5-méthanesulfonyl-2-((S)-2,2,2-trifluoro-1-méthyl-éthoxy)-phényl]-méthanone, et leur utilisation pour la préparation de compositions pharmaceutiques. Les composés selon la présente invention peuvent être utilisés pour la préparation d'un médicament utile pour traiter les psychoses, la douleur, la dysfonction neurodégénérative de la mémoire et de l'apprentissage, la schizophrénie, la démence et d'autres maladies dans lesquelles les processus cognitifs sont détériorés, par exemple les troubles déficitaires de l'attention ou la maladie d'Alzheimer.

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