Crystalline forms of...

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C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/4245 (2006.01)

Patent

CA 2663574

The present invention relates to crystalline forms of 3- [5- (2 -fluorophenyl) - [l,2,4]oxadiazol-3-yl] -benzoic acid (formula (I)), pharmaceutical compositions and dosage forms comprising the crystalline forms, methods of making the crystalline forms and methods for their use for the treatment, prevention or management of diseases ameliorated by modulation of premature translation termination or nonsense -mediated mRNA decay.

L'invention concerne des formes cristallines de l'acide 3-[5-(2-fluorophényl)-[1,2,4]oxadiazol-3-yl]benzoïque, des compositions pharmaceutiques et formes de dosage comprenant les formes cristallines, des procédés de fabrication des formes cristallines et des procédés d'utilisation de celles-ci pour le traitement, la prévention ou la gestion de maladies améliorés par la modulation de la fin de traduction prématurée ou de la dégradation des ARNm portant un codon non-sens (NMD).

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