C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/519 (2006.01) A61P 1/00 (2006.01) A61P 13/00 (2006.01)
Patent
CA 2647329
The present invention is directed to novel crystalline forms of 4-(2-fIuorophenyl)-6-methyl-2-(piperazin-l-yl)thieno[2,3-d]py.tau.imidine salts, including 4-(2- fluorophenyl)-6-methyl-2-(piperazin- 1 -yl)thieno[2,3-d]pyrimidine hydrochloride crystalline forms. The present invention is also directed to compositions including such crystalline forms and methods for making and using such crystalline forms, e.g., in the treatment of gastrointestinal and/or genitourinary disorders.
La présente invention concerne de nouvelles formes cristallines de sels 4-(2- fluorophényl)-6-méthyl-2-(pipérazin-l-yl)thiéno[2,3-d]pyrimidine, y compris les formes cristallines de 4-(2- fluorophényl)-6-méthyl-2-(pipérazin-l-yl)thiéno[2,3-d]pyrimidine hydrochlorure. Cette invention concerne également des compositions contenant de telles formes cristallines et des procédés de préparation et d'utilisation de ces formes cristallines, par exemple dans le traitement des troubles gastro-intestinaux et/ou génito-urinaires.
Cooper Martin Ian
Frampton Christopher Stephen
Dynogen Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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