C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/09 (2006.01) A61K 31/437 (2006.01) A61P 31/18 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2635717
The instant disclosure provides crystalline forms of 1-benzoyl-4-[2-[4-methoxy- 7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3- c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine, salts and solvates thereof. The present disclosure also generally relates to pharmaceutical compositions comprising the crystalline form(s), as well of methods of using the crystalline form(s) in the treatment of HIV and/or AIDS, and methods for obtaining such crystalline form(s).
La présente invention concerne des formes cristallines de 1-benzoyl-4-[2-[4-méthoxy-7-(3-méthyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)méthyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoéthyl]-pipérazine, de ses sels et de ses solvates. L'invention concerne également d'une manière générale des compositions pharmaceutiques comprenant ces formes cristallines, ainsi que des procédés d'utilisation de ces formes cristallines pour le traitement du VIH et/ou du SIDA et des procédés de préparation de ces formes cristallines.
Chen Chung-Pin H.
Digiugno Dawn
Gao Qi
Gu Chong-Hui
Levons Jaquan Kalani
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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