Crystalline forms of 1s-[1alpha (2s*,3r*), 9alpha]-6,...

Details Crystalline forms of 1s-[1alpha (2s*,3r*), 9alpha]-6,... Crystalline forms of 1s-[1alpha (2s*,3r*), 9alpha]-6,...

C - Chemistry, Metallurgy

07

K

C07K 5/023 (2006.01) A61K 38/06 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2325629

The invention concerns novel crystalline forms of 1S-[1alpha(2S*, 3R*),9alpha]-6, 10-dioxo-N- (2-ethoxy-5 -oxo-tetrahydro-3 -furanyl)-9-[[( 1-isoquinolyl) carbonyl]-amino] octahydro-6H -piridazino[1, 2-a][1,2]diazepin-1 -carboxamide, anhydrous (form A) and hydrated (form B), the method for preparing them, their use as medicine and the pharmaceutical compositions containing them.

L'invention a pour objet les nouvelles formes cristallines du 1S-[1alpha(2S*, 3R*),9alpha]6, 10-dioxo-N- (2-éthoxy-5 -oxo-tétrahydro-3 -furanyl)-9 [[( 1- isoquinolyl) carbonyl]amino] octahydro-6H -piridazino[1, 2-a][1 ,2]diazepine-1 -carboxamide anhydre (forme A) et hydratée (forme B), leur procédé de préparation, leur application à titre de médicament et les compositions pharmaceutiques les renfermant.

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