Crystalline forms of...

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C - Chemistry, Metallurgy

07

C

C07C 237/22 (2006.01) A61K 31/197 (2006.01) A61P 1/16 (2006.01)

Patent

CA 2669849

The present invention relates to crystalline forms of (3S)-3-[N-(N'-(2-tert- butylphenyl)oxamyl)alaninyl]amino-5-(2',3',5',6'-tetrafluorophenoxy)-4-oxopentanoic acid (see formula (I)). The invention further relates to pharmaceutical compositions comprising such crystalline forms and to the use of said pharmaceutical compositions and said crystalline forms in the treatment of various conditions, particularly in the treatment of liver fibrosis.

La présente invention concerne les formes cristallines de l'acide (3S)-3-[N-(N'-(2-tert-butyphényl)oxamyl)alaninyl]amino-5-(2',3',5',6'-tétrafluorophénoxy)-4-oxopentanoïque (voir formule (I)). L'invention concerne en outre des compositions pharmaceutiques comprenant de telles formes cristallines et l'utilisation desdites compositions pharmaceutiques et desdites formes cristallines dans le traitement de diverses conditions, en particulier dans le traitement de la fibrose du foie.

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