Crystalline forms of a 3-carboxypropyl-aminotetralin compound

Details Crystalline forms of a 3-carboxypropyl-aminotetralin compound Crystalline forms of a 3-carboxypropyl-aminotetralin compound

C - Chemistry, Metallurgy

07

C

C07C 231/24 (2006.01) C07C 237/48 (2006.01)

Patent

CA 2745441

The invention provides crystalline solid forms of (S)-4-((2S,3S)-7-carbamoyl- l,l-diethyl-3-methoxy-1,2,3,4- tetrahydronaphthalen-2-ylamino)-2-cyclohexylmethyl-butyric acid. The invention also provides pharmaceutical compositions comprising such crystalline solid forms, methods of using such crystalline solid forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline solid forms.

L'invention concerne des formes solides cristallines d'acide (S)-4-((2S,3S)-7-carbamoyl-1,1-diéthyl-3-méthoxy-1,2,3,4-tétrahydronaphthalène-2-ylamino)-2-cyclohexylméthyl-butyrique. L'invention concerne aussi des compositions pharmaceutiques comprenant de telles formes solides cristallines, des procédés d'utilisation de ces formes solides cristallines pour traiter des maladies associées à l'activité des récepteurs opioïdes mu, et des procédés utiles pour élaborer ces formes solides cristallines.

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