Crystalline forms of a dimethylphenyl compound

C - Chemistry – Metallurgy – 07 – D

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C07D 211/46 (2006.01) A61K 31/445 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2650631

The invention relates to crystalline free base forms of biphenyl-2-ylcarbamic acid 1-[2-(4-{[(R)-2-(3-formylamino-4-hydroxyphenyl)-2-hydroxyethylamino]methyl}-2,5-dimethylphenylcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof. This invention also relates to pharmaceutical compositions containing or prepared from such crystalline forms; processes and intermediates useful for preparing such crystalline forms; and methods of using such crystalline forms to, for example, treat a pulmonary disorder.

L'invention concerne des formes à bases libres cristallines de 1-[2-(4-{[(R)-2-(3-formylamino-4-hydroxyphényl)-2-hydroxyéthylamino]méthyl}-2,5-diméthylphénylcarbamoyl)éthyl]pipéridin-4-yl ester de l'acide diphényl-2-ylcarbamique ou un solvate de celles.ci. L'invention concerne également des compositions pharmaceutiques contenant lesdites formes cristallines ou préparées à partir de celles-ci; des procédés et des intermédiaires utiles pour la préparation desdites formes cristallines; ainsi que des méthodes d'utilisation desdites formes cristallines pour, par exemple, traiter un trouble pulmonaire.

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