Crystalline forms of a factor xa inhibitor

Details Crystalline forms of a factor xa inhibitor Crystalline forms of a factor xa inhibitor

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2589886

The instant invention provides crystalline forms of 3-(1-hydroxy-1-methyl- ethyl)-1-(4-methoxy-phenyl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-1,4,5,6- tetrahydro-pyrazolo[3,4-c]pyridin-7-one and its solvates thereof; processes for the production of such crystalline forms; pharmaceutical compositions comprising such crystalline forms; and methods of treating thromboembolic disorders with such crystalline forms or such pharmaceutical compositions.

L'invention concerne des formes cristallines de 3-(1-hydroxy-1-méthyl-éthyl)-1-(4-méthoxy-phényl)-6-[4-(2-oxo-2H-pyridin-1-yl)-phényl]-1,4,5,6-tétrahydro-pyrazolo[3,4-c]pyridin-7-one et des solvates de celles-ci. Elle concerne également des procédés de production de ces formes cristallines, des compositions pharmaceutiques les contenant et des procédés de traitement de troubles thromboemboliques au moyen de ces formes cristallines ou de ces compositions pharmaceutiques.

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