Crystalline forms of an 8-azabicyclo[3.2.1]octane compound

Details Crystalline forms of an 8-azabicyclo[3.2.1]octane compound Crystalline forms of an 8-azabicyclo[3.2.1]octane compound

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2678073

The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.

L'invention concerne un sel de sulfate cristallin de 3-endo-(8-{2-[cyclohexylméthyl-((S)-2,3-dihydroxy-propionyl)amino]éthyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide ou un solvate de celui-ci. L'invention fournit également des compositions pharmaceutiques comprenant de telles formes de sel cristallin, des procédés d'utilisation de telles formes de sel cristallin pour traiter des maladies associées à l'activité de récepteur opioïde mu et des procédés utiles pour préparer de telles formes de sel cristallin.

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