Crystalline forms of (+)- and (-)-erythro-mefloquine...

Details Crystalline forms of (+)- and (-)-erythro-mefloquine... Crystalline forms of (+)- and (-)-erythro-mefloquine...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2543076

(+)- or (-)-erythro-Mefloquine hydrochloride can exist in four crystalline forms A, B, C and D, whereby form A is the most stable form. Form A can be directly produced in morphological forms like thick columns, cuboids, cubes and cube-like forms, which can be easily handled during processing and formulation. (+)- or (-)-eroryth-Mefloquine hydrochloride also forms solvates with acetone, methyl ethyl ketone and tetrahydrofuran.

L'invention concerne de l'hydrochlorure d'érythro-méfloquine (+)ou (-) pouvant se présenter sous quatre formes cristallines A, B, C et D. La forme A constitue la forme la plus stable, la forme A peut être produite directement sous des formes morphologiques de type colonnes épaisses, cuboïdes, cubes et des formes de type cubique, pouvant être facilement manipulées lors d'un traitement et d'une formulation. L'hydrochlorure d'érythro-méfloquine (+) ou (-) permet également de former des solvates avec de l'acétone, de la méthyle éthyle cétone et du tétrahydrofurane.

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