Crystalline forms of dmxaa sodium salt

Details Crystalline forms of dmxaa sodium salt Crystalline forms of dmxaa sodium salt

C - Chemistry, Metallurgy

07

D

C07D 311/86 (2006.01)

Patent

CA 2702301

The present invention relates to pharmaceutically stable crystalline forms of (5, 6-Dimethyl-9- oxo-9H-xanthene-4-yl) acetic acid (DMXAA) sodium salt,- processes for preparing those stable crystalline forms; pharmaceutical compositions comprising at least one of those crystalline forms in solid form or in dissolved form and a pharmaceutically acceptable carrier. Disclosed are methods of using those pharmaceutical compositions to treat tumours, optionally in combination with other active pharmaceutical agents.

L'invention concerne des formes cristallines pharmaceutiquement stables d'un sel de sodium d'acide (5,6-diméthyl-9-oxo-9H~xanthène-4-yl) acétique (DMXAA); des procédés de préparation desdites formes cristallines stables; des compositions pharmaceutiques renfermant au moins l'une desdites formes cristallines sous forme solide ou sous forme dissoute et un véhicule pharmaceutiquement acceptable. L'invention porte également sur des procédés d'utilisation desdites compositions pharmaceutiques, facultativement combinées à d'autres agents pharmaceutiques, dans le traitement de tumeurs.

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