Crystalline forms of erlotinib base and erlotinib hcl

Details Crystalline forms of erlotinib base and erlotinib hcl Crystalline forms of erlotinib base and erlotinib hcl

C - Chemistry, Metallurgy

07

D

C07D 239/94 (2006.01)

Patent

CA 2730226

The preparation of crystalline Erlotinib base form G2 is described. This crystalline form can be converted to an Erlotinib salt, such as Erlotinib HCl, which can be used in the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).

L'invention porte sur la préparation de la forme cristalline G2 de l'Erlotinib base. Cette forme cristalline peut être convertie en un sel d'Erlotinib, tel que le chlorhydrate d'Erlotinib, qui peut être utilisé dans le traitement de patients atteint d'un cancer du poumon non à petites cellules (NSCLC) localement avancé ou métastasé.

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