Crystalline forms of fluvastatin sodium

Details Crystalline forms of fluvastatin sodium Crystalline forms of fluvastatin sodium

C - Chemistry, Metallurgy

07

D

C07D 209/24 (2006.01) A61K 31/405 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2426395

Crystalline forms of the (3R,5S)- and the (3S,5R)-enantiomer of fluvastatin were found, referred to hereinafter as polymorphic Forms A, B1, B2, C, D and E. Furthermore, the present invention is directed to processes for the preparation of these crystalline forms and pharmaceutical compositions comprising the crystalline forms.

La présente invention concerne des formes cristallines de l'énantiomère (3R,5S)- et de l'énantiomère (3S,5R) de fluvastatine, dénommées formes polymorphes A, B1, B2, C, D et E. De plus, la présente invention concerne des procédés de préparation desdites formes cristallines et des compositions pharmaceutiques comprenant ces formes cristallines.

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