Crystalline forms of quetiapine hemifumarate

Details Crystalline forms of quetiapine hemifumarate Crystalline forms of quetiapine hemifumarate

C - Chemistry, Metallurgy

07

D

C07D 417/04 (2006.01) A61K 31/554 (2006.01)

Patent

CA 2479668

The present invention relates to novel crystalline forms of quetiapine hemifumarate (I), denominated quetiapine hemifuramate form II and quetiapine hemifuramate form III. These novel crystalline forms of quetiapine hemifuramate have been characterized by methods including x-ray powder diffraction (XRD), Fourier transform IR spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermal gravimetric analysis (TGA). Methods for preparation of the novel crystalline quetiapine hemifuramate form II as its chloroform solvate and its dichloromethane solvate, form III as its chloroform solvate, and form I are provided.

La présente invention concerne de nouvelles formes d'hémifumarate de quétiapine (I) en l'occurrence l'hémifumarate de quétiapine de forme II et l'hémifumarate de quétiapine de forme III. Ces nouvelles formes d'hémifumarate de quétiapine ont été caractérisées au moyen de procédés incluant la diffraction de rayons X sur poudre (XRD), la spectrométrie infrarouge à transformée de Fourier (FTIR), l'analyse calorimétrique différentielle (DSC), et l'analyse gravimétrique par procédé thermique TGA). L'invention concerne également des procédés permettant l'élaboration du nouvel hémifumarate de quétiapine de forme cristalline II en tant que son solvat de chloroforme et son solvat de dichlorométhane, de forme cristalline III en tant que son solvat de chloroforme, et de forme cristalline I.

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