Crystalline forms of (r) -5- [3-chloro-4- ( 2,...

Details Crystalline forms of (r) -5- [3-chloro-4- ( 2,... Crystalline forms of (r) -5- [3-chloro-4- ( 2,...

C - Chemistry, Metallurgy

07

D

C07D 277/54 (2006.01) A61K 31/426 (2006.01) A61P 3/10 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2740313

The invention relates to crystalline forms of (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)-benz[Z]ylidene]-2-([Z]--propylimino)- 3-o-tolyl-thiazolidin-4-one, processes for the preparation thereof, pharmaceutical compositions containing said crys-talline forms, and their use as compounds improving vascular function and as immunomodulating agents, either alone or in combi-nation with other active compounds or therapies.

La présente invention concerne des formes cristallines de la (R)-5[3-chloro-4-(2,3-dihydroxy-propoxy)-benz-[Z]-ylidène]-2-([Z]-propylimino)-3-O-tolyl-thiazolidin-4-one, des procédés pour leur préparation, des compositions pharmaceutiques contenant lesdites formes cristallines, et leur utilisation comme composés améliorant la fonction vasculaire et comme agents immunomodulateurs, soit seuls, soit en association avec dautres composés actifs ou thérapies.

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