Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,...

Details Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,... Crystalline forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,...

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2521956

Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta., .DELTA.;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H- pyrrole-1-heptanoic acid hemi calcium salt atorvastatin designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid- state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.

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