Crystalline forms of rabeprazole sodium

Details Crystalline forms of rabeprazole sodium Crystalline forms of rabeprazole sodium

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01)

Patent

CA 2480358

The present invention relates to novel polymorphic forms of Rabeprazole sodium. The present invention also relates to methods of making polymorphic forms of Rabeprazole sodium. Achiphex7 (Rabeprazole sodium) is an inhibitor of the gastric proton pump. It causes dose-dependant inhibition of acid secretion and is useful as an antiulcer agent. The chemical designation of Rabeprazole sodium is 2-[[[4-(3-methoxypropoxy)-3 methyl-2-pyridinyl]-methyl] sulfinyl]-1H- benzimidazole sodium. It may be represented by Formula (1).

L'invention concerne de nouvelles formes polymorphes de rabéprazole sodique, ainsi que des procédés de préparation de formes polymorphes de rabéprazole sodique. L'achiphex 7 (rabéprazole sodique) est un inhibiteur de la pompe à protons gastriques. Il induit une inhibition proportionnelle à la dose administrée de sécrétion d'acide et s'utilise comme agent anti-ulcéreux. La désignation chimique du rabéprazole sodique est 2-[[[4-(3-méthoxypropoxy)-3-méthyle-2-pyridinyle]-méthyle]sulfinyle]-1<I>H</I>-benzimidazole sodium. Il peut être représenté par la formule (I).

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