Crystalline forms of solvated ilaprazole

Details Crystalline forms of solvated ilaprazole Crystalline forms of solvated ilaprazole

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2674358

The invention relates to crystalline forms of various solvates of ilaprazole, 2[[(4-methoxy-3- methyl-2-pyridinyl)-methyl]sulfinyl]-5-(lH-pyrrol-l-yl) 1H-Benzimidazole. The invention also relates to a pharmaceutical composition for inhibiting gastric acid secretion comprising crystalline ilaprazole hydrate according to the invention in an amount effective to inhibit gastric acid secretion and a pharmaceutically acceptable carrier. The invention also provides methods of treatment for various acid-related gastrointestinal (GI) disorders.

L'invention concerne des formes cristallines de divers solvates d'ilaprazole, le 2[[(4-méthoxy-3- méthyl-2-pyridinyl)-méthyl]sulfinyl]-5-(lH-pyrrol-l-yl) 1H-Benzimidazole. L'invention concerne également une composition pharmaceutique pour inhiber la sécrétion d'acide gastrique comprenant un hydrate d'ilaprazole cristallin selon l'invention en une quantité efficace pour inhiber la sécrétion d'acide gastrique et un véhicule pharmaceutiquement acceptable. L'invention concerne également des procédés de traitement pour divers troubles gastro-intestinaux liés aux acides (GI).

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