C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61P 3/10 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2665048
It is an object of the present invention to provide the crystalline form of a thiazolidinedione compound, which is effective as a pharmaceutical ingredient for manufacturing a peroxisome proliferator-activated receptor (PPAR) activator and an anticancer pharmaceutical composition. The present invention relates to a crystalline form of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride represented by the following formula (I). [Formula 1]
La présente invention concerne la production de la forme cristalline d'un composé de thiazolidinedione qui est efficace en tant qu'ingrédient pharmaceutique pour préparer un activateur du récepteur activé par un proliférateur peroxisome (PPAR) et une composition pharmaceutique anticancéreuse. Cette invention concerne une forme cristalline d'un hydrate de 5-(4-{[6-(4-amino-3,5-diméthylphénoxy)-1-méthyl-1-H- benzimidazol-2-yl]méthoxy}benzyl)-1,3-thiazolidine-2,4- dione dihydrochlorure représenté par la formule (I). [Formule 1]
Ikeuchi Yutaka
Kajino Hisaki
Miyamoto Hiroshi
Nihei Satoru
Numagami Eiji
Daiichi Sankyo Company Limited
Marks & Clerk
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