Crystalline forms vi and vii of atorvastatin calcium

Details Crystalline forms vi and vii of atorvastatin calcium Crystalline forms vi and vii of atorvastatin calcium

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01)

Patent

CA 2454500

The present invention relates to novel crystalline forms of atorvastatin calcium and to the methods of their production and isolation. More specifically, the present invention relates to novel Forms VI and VII of R- (R*, R*)]-2(4-fluorophenyl)-B, d dihydroxy-5(1-methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]-1-H-pyrrole-1-heptanoic- acid calcium salt and hydrates thereof and to methods of their preparation.

L'invention concerne des nouvelles formes cristallines de calcium d'atorvastatine et des procédés de préparation et d'isolation associés. Plus précisément, l'invention concerne des nouvelles formes VI et VII des sels de calcium de l'acide R-(R?*¿, R?*¿)]-2(4-fluorophényl)-B, d dihydroxy-5(1-méthyléthyl)-3-phényl-4-[(phénylamino)carbonyl]-1-H-pyrrole-1-heptanoïque et d'hydrates de ceux-ci et des procédés de préparation associés.

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