Crystalline glucosamine sulphate metal salts

C - Chemistry – Metallurgy – 07 – H

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C07H 5/06 (2006.01) A61K 31/70 (2006.01) C07H 5/04 (2006.01)

Patent

CA 2436925

The present invention relates to novel crystalline glucosamine sulphate metal salts for use in the treatment of acute and chronic forms of rheumatic and arthritic diseases and of all the pathological conditions originating from metabolic disorders of the osteo-articular tissues. More particularly, the present invention relates to novel crystalline glucosamine sulphate metal salts having low metal content wherein the metal may be either sodium or potassium. The present invention further relates to a solution-based and a solvent-free process for the preparation of the novel crystalline glucosamine sulphate metal salts having low metal content and to pharmaceutical compositions comprising the novel crystalline glucosamine sulphate metal salts having low metal content.

La présente invention concerne de nouveaux sels métalliques de sulfate de glucosamine cristallin destinés au traitement de formes aiguës et chroniques de maladies rhumatismales et arthritiques et de tous les états pathologiques dus à des troubles métaboliques des tissus ostéo-articulaires. Cette invention concerne plus particulièrement de nouveaux sels métalliques de sulfate de glucosamine cristallin à faible contenu métallique et dont le métal peut être soit du sodium soit du potassium. Cette invention concerne aussi un processus à base de solution et sans solvant destiné à la préparation de ces nouveaux sels métalliques de sulfate de glucosamine cristallin à faible contenu métallique et des compositions pharmaceutiques comprenant ces nouveaux sels métalliques de sulfate de glucosamine cristallin à faible contenu métallique.

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