Crystalline hydrate of betamimetika and use as medicament...

Details Crystalline hydrate of betamimetika and use as medicament... Crystalline hydrate of betamimetika and use as medicament...

C - Chemistry, Metallurgy

07

D

C07D 265/36 (2006.01) A61K 31/538 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2703511

The present invention relates to a crystalline, enantiomerically pure hydrate of R-6-hydroxy-8-(1-hydroxy -2-[2-(4-methoxy-phenyl)-1,1-dimethyl-ethylamino] -ethyl}-4H-benzo[1,4]oxazin-3-one-hydrochloride of formula (1) and its activity as a long-acting betamimetic, on its own or combined with one or more other active substances for treating respiratory complaints.

La présente invention concerne un hydrate cristallin pur sur le plan énantiomère du chlorhydrate de R-6-hydroxy-8-{1-hydroxy-2-[2-(4-méthoxy-phényl)-1,1-diméthyl-éthylamino]-éthyl}-4H-benzo[1,4]oxazin-3-one de formule (1) et son activité en tant que bêta-mimétique à action prolongée, par lui-même ou combiné à une ou plusieurs autres substances actives pour le traitement de symptômes respiratoires.

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