Crystalline hydrochloride of (r)-(-)-2...

Details Crystalline hydrochloride of (r)-(-)-2... Crystalline hydrochloride of (r)-(-)-2...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/425 (2006.01)

Patent

CA 2190700

The invention relates to the crystalline form of the hydrochloride of the compound (R)- (-)2-{N-[4(1,1-dioxido-3-oxo-2,3-dihydro-benzisothiazol-2-yl}butyl]-aminomethyl}- chroman, which is present as a stable form at room temperature. The crystalline modification V of the hydrochloride is suitable in particular for the preparation of solid medicaments,in particular of medicaments for the treatment of neuronal degenerations.

ette invention décrit la forme cristalline du chlorhydrate du composé (R)- (-)2-{N-[4(1,1-dioxido-3-oxo-2,3-dihydro-benzisothiazol-2-yl}butyl]-aminométhyl}- chromane, qui est présent sous une forme stable à la température ambiante. La forme cristalline modifiée V du chlorhydrate peut servir entre autres à la préparation de médicaments solides, et particulièrement à celle de médicaments pour le traitement de cas de dégénérescence neuronale.

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