Crystalline minocycline base and processes for its preparation

Details Crystalline minocycline base and processes for its preparation Crystalline minocycline base and processes for its preparation

C - Chemistry, Metallurgy

07

C

C07C 237/26 (2006.01)

Patent

CA 2722496

The invention provides crystalline minocycline base. In particular, three crystalline polymorphic forms, designated Form I, Form 11 and Form III, of minocycline base are provided. These are characterised by XRD and IR data. Processes for preparing the new polymorphic forms are also provided. For example, Form I is prepared by dissolving and/or suspending amorphous minocycline base in an organic solvent chosen from ethers followed by crystallisation from the mixture.

L'invention concerne une base de minocycline cristalline. L'invention concerne en particulier trois formes cristallines polymorphes, désignées sous le nom de forme I, forme Il et forme III, d'une base de minocycline. Celles-ci se caractérisent par des données XRD et IR. L'invention concerne également des procédés de préparation des nouvelles formes polymorphes. Par exemple, la forme I est préparée par dissolution et/ou suspension de la base de minocycline amorphe dans un solvant organique sélectionné parmi des éthers, puis par cristallisation du mélange.

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