Crystalline modification of...

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C - Chemistry, Metallurgy

07

D

C07D 417/10 (2006.01) A61K 31/541 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2514037

The present invention relates to a new crystalline modification of 2-(3,5-bis- trifluoromethyl-phenyl)-N-[6-(1,1-dioxo-1.lambda.6-thiomorpholin-4-yl)-4(4- fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide characterized by the following X-ray diffraction pattern obtained with a CUK.alpha.radiationat 2.theta. (2Theta)= 4.5, 6.4, 7.5, 7.7, 8.0, 8.2, 10.0, 10.2, 10.9, 11.1, 12.9, 13.4, 14.0, 14.5, 15.1, 15.6, 16.2, 16.5, 17.3, 17.5, 18.0, 18.9, 19.3, 19.5, 19.9, 20.1, 20.6, 21.0, 21.4, 22.7, 23.1 and 23.6 and an infrared spectrum having sharp bands at 2925, 2845, 1637, 1604, 1484, 1395, 1375, 1285, 1230, 1172, 1125, 1082, 999, 943, 893, 863, 860, 782, 705, 684 cm-1, and wherein the extrapolated melting point (DSC) is 137.2~C.

Cette invention a trait à une nouvelle modification cristalline de 2-(3,5-bis-trifluorométhyl-phényl)-N-[6-(1,1-dioxo-1??6¿-thiomorpholin-4-yl)-4(4-fluoro-2-méthyl-phényl)-pyridine-3-yl]-N-méthyl-isobutyramide se caractérisant par une configuration de diffraction des rayons X obtenue avec un rayonnement 2? (2 Thêta)= 4.5, 6.4, 7.5, 7.7, 8.0, 8.2, 10.0, 10.2, 10.9, 11.1, 12.9, 13.4, 14.0, 14.5, 15.1, 15.6, 16.2, 16.5, 17.3, 17.5, 18.0, 18.9, 19.3, 19.5, 19.9, 20.1, 20.6, 21.0, 21.4, 22.7, 23.1 et 23.6 ainsi que par un spectre dans l'infrarouge ayant des bandes aiguës à 2925, 2845, 1637, 1604, 1484, 1395, 1375, 1285, 1230, 1172, 1125, 1082, 999, 943, 893, 863, 860, 782, 705, 684 cm?-1¿, la température de fusion extrapolée étant de 137, 2 ·C.

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